Thannickal Lab / Research Projects
The scientific questions we are working to answer.
Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease
Understand the links between cellular redox control and metabolic reprogramming, uncover novel regulatory mechanisms of macrophage polarization, and uncoverpreviously unrecognizedconnections between innate/adaptive immunity, epigenetics and lung fibrosis. Importantly, this tPPGwill advance a novel anti-fibrotic drug therapy that more specifically targets redox biology in IPF, which will enable future Phase III clinical trials.
