Publications – Thannickal Lab

Impactful advances & discoveries.

Aging Cell · 2021-09-21

Mitochondrial uncoupling protein-2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age-associated lung fibrosis

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Sci Transl Med . · 2014-04-09

Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance

The Journal of clinical investigation · 2024-11-21

The lung mesenchyme in development, regeneration, and fibrosis.

The Journal of biological chemistry · 2024-11-21

Nicotinamide N-methyltransferase mediates lipofibroblast-myofibroblast transition and apoptosis resistance.

Nature Aging · 2024-11-21

Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice.

eLife · 2024-11-21

Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells.

Nature Medicine · 2018-08-24

Metformin reverses established lung fibrosis in a bleomycin model

Groundbreaking discoveries.