Pursell Lab / Publications
Browse the latest scientific discoveries and advances from our lab.
| Title | Journal | Date | Projects | Funding |
|---|---|---|---|---|
| POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status. | Molecular cell | 2024-12-22 | ||
| Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development. | NAR cancer | 2024-12-22 | ||
| Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade. | Cancer research | 2024-12-22 | ||
| Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair. | eLife | 2024-12-22 |
