Publications – Mauvais-Jarvis Lab

Impactful advances & discoveries.

Cell reports · 2018-06-01

Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes.

Diabetes · 2018-10-10

Loss of nuclear and membrane estrogen receptor-α differentially impairs insulin secretion and action in male and female Mice.

Diabetes · 2020-08-27

Intracrine testosterone activation in human pancreatic β-Cells stimulates insulin secretion.

Cell reports. Medicine · 2022-04-07

Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and pre-clinical models of insulin-deficient diabetes.

Nature reviews. Nephrology · 2023-11-03

Sex differences in energy metabolism: natural selection, mechanisms and consequences.

Cell reports · 2023-05-17

Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells.

EMBO Journal · 2024-11-20

Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes

JCI insight · 2021-08-23

SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes.

Molecular metabolism · 2019-02-14

Activation of hepatic estrogen receptor-α increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice.

Cell metabolism · 2016-05-10

Extranuclear actions of the androgen receptor enhance glucose-stimulated insulin secretion in the male.

JCI insight · 2018-06-21

Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes.

Groundbreaking discoveries.