Publications – Mauvais-Jarvis Lab

Impactful advances & discoveries.

Cell reports · 2018-06-01

Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes.

Diabetes · 2018-10-10

Loss of Nuclear and Membrane Estrogen Receptor-α Differentially Impairs Insulin Secretion and Action in Male and Female Mice.

Diabetes · 2020-08-27

Intracrine Testosterone Activation in Human Pancreatic β-Cells Stimulates Insulin Secretion.

Cell reports. Medicine · 2022-04-07

Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and pre-clinical models of insulin-deficient diabetes.

Nature reviews. Nephrology · 2023-11-03

Sex differences in energy metabolism: natural selection, mechanisms and consequences.

Cell reports · 2023-05-17

Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells.

bioRxiv : the preprint server for biology · 2024-04-22

Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes.

JCI insight · 2021-08-23

SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes.

Molecular metabolism · 2019-02-14

Activation of hepatic estrogen receptor-α increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice.

Cell metabolism · 2016-05-10

Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male.

JCI insight · 2018-06-21

Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes.

Groundbreaking discoveries.