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Cell and Molecular Biology of L1
The human genome is infested with hundreds of thousands of sequences called retrotransposons. Retrotransposons can self-replicate and insert their sequence semi-randomly back into the genome to generate mutations. In humans, an element called Long Interspersed Nuclear Element-1 (LINE-1, or L1) is the current dominant retrotransposon. L1 controls essentially all transposition in humans.
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Browse the latest scientific discoveries and advances from our lab.
Mobile DNA · 2026-05-02
Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions.
Read publicationMobile DNA · 2026-05-02
Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs.
Read publicationNucleic acids research · 2026-05-02
Circular retrotransposition products generated by a LINE retrotransposon.
Read publicationScience (New York, N.Y.) · 2026-05-02
Total synthesis of a functional designer eukaryotic chromosome.
Read publicationMethods in molecular biology (Clifton, N.J.) · 2016-02-20
LINE Retrotransposition Assays in Saccharomyces cerevisiae.
Read publicationNucleic acids research · 2026-05-02
Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity.
Read publicationPLoS genetics · 2026-05-02
A conserved role for the ESCRT membrane budding complex in LINE retrotransposition.
Read publicationBioEssays : news and reviews in molecular, cellular and developmental biology · 2005-07-13
LINE-1 retrotransposons: modulators of quantity and quality of mammalian gene expression?
Read publicationGenome research · 2026-05-02
Gene-breaking: a new paradigm for human retrotransposon-mediated gene evolution.
Read publicationProceedings of the National Academy of Sciences of the United States of America · 2026-05-02
Active retrotransposition by a synthetic L1 element in mice.
Read publicationGenesis (New York, N.Y. : 2000) · 2008-07-09
Conditional activation of a single-copy L1 transgene in mice by Cre.
Read publicationNature · 2004-05-20
Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes.
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