{"id":307,"date":"2024-05-20T22:05:50","date_gmt":"2024-05-20T22:05:50","guid":{"rendered":"https:\/\/labs.tulane.edu\/mauvais-jarvis-lab\/research-projects\/role-of-the-androgen-receptor-in-insulin-secretion-in-the-male\/"},"modified":"2024-05-22T19:31:04","modified_gmt":"2024-05-22T19:31:04","slug":"role-of-the-androgen-receptor-in-insulin-secretion-in-the-male","status":"publish","type":"research-projects","link":"https:\/\/labs.tulane.edu\/mauvais-jarvis-lab\/research-projects\/role-of-the-androgen-receptor-in-insulin-secretion-in-the-male\/","title":{"rendered":"Role of the Androgen Receptor in Insulin Secretion in the Male"},"content":{"rendered":"\n<p>The role of testosterone deficiency as a cause of pancreatic beta\u2013cell dysfunction predisposing to type 2 diabetes (T2D) in men is poorly studied. While it is established that testosterone action is mediated via the AR, a ligand-activated transcription factor, the role of the AR in beta-cell function is still poorly understood. Our published far-reaching preliminary data demonstrated that testosterone action on the androgen receptor (AR) in male insulin-producing pancreatic beta-cells enhances insulin secretion by amplifying glucagon-like peptide-1 (GLP-1) actions. The goal of this project is to further elucidate the molecular bases by which DHT-activated AR stimulates cAMP production and enhances GLP-1 signaling at the plasma membrane and endosomes to increase insulin secretion in males. This study will fill key gaps in our understanding of the fundamental mechanisms of beta-cell function and will have a lasting scientific impact and open clinically relevant avenues for androgen-deficient male with diabetes.<\/p>\n","protected":false},"template":"","acf":[],"_links":{"self":[{"href":"https:\/\/labs.tulane.edu\/mauvais-jarvis-lab\/wp-json\/wp\/v2\/research-projects\/307"}],"collection":[{"href":"https:\/\/labs.tulane.edu\/mauvais-jarvis-lab\/wp-json\/wp\/v2\/research-projects"}],"about":[{"href":"https:\/\/labs.tulane.edu\/mauvais-jarvis-lab\/wp-json\/wp\/v2\/types\/research-projects"}],"wp:attachment":[{"href":"https:\/\/labs.tulane.edu\/mauvais-jarvis-lab\/wp-json\/wp\/v2\/media?parent=307"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}