Spatial Multiomics Core is a new branch of COBRE Genomics, Bioinformatics and Spatial Multiomics Cores –Tulane Center For Aging. Spatial Multiomics Core is responsible for running 10X Visium spatial slide. The Visium Spatial Gene Expression Solution measures total mRNA in intact tissue sections and maps the location(s) where gene activity is occurring. Each Visium Spatial Gene Expression Slide contains Capture Areas with gene expression spots that include primers required for capture and priming of poly-adenylated mRNA. Tissue sections placed on these Capture Areas are fixed and stained All the cDNA generated from mRNA captured by primers on a specific spot share a common Spatial Barcode. Libraries are generated from the cDNA and sequenced and the Spatial Barcodes are used to associate the reads back to the tissue section images for spatial gene expression mapping.
Learn more about our current members, alumni, and collaborators.
Mimi Sammarco
Learn moreAhmed Moustafa
Learn moreBrowse the latest scientific discoveries and advances from our lab.
Scientific reports · 2024-11-21
Sirtuin 3 deficiency does not impede digit regeneration in mice.
Read publicationBone · 2024-11-21
A new approach to analyzing regenerated bone quality in the mouse digit amputation model using semi-automatic processing of microCT data.
Read publicationClinical orthopaedics and related research · 2019-09-03
Letter to the Editor: Editorial: Beware of Studies Claiming that Social Factors are "Independently Associated" with Biological Complications of Surgery.
Read publicationUrology · 2024-11-21
Pioglitazone Enhances Survival and Regeneration of Pelvic Ganglion Neurons After Cavernosal Nerve Injury.
Read publicationFrontiers in oncology · 2024-11-21
Interleukin-17 Promotes Migration and Invasion of Human Cancer Cells Through Upregulation of MTA1 Expression.
Read publicationAmerican journal of clinical and experimental urology · 2024-11-21
Th17 cells promote tumor growth in an immunocompetent orthotopic mouse model of prostate cancer.
Read publicationRegeneration (Oxford, England) · 2024-11-21
Fibroblast reticular cells engineer a blastema extracellular network during digit tip regeneration in mice.
Read publicationJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015-02-20
Endogenous bone regeneration is dependent upon a dynamic oxygen event.
Read publicationDevelopmental dynamics : an official publication of the American Association of Anatomists · 2024-11-21
Characterizing the role of Pdgfra in calvarial development.
Read publicationDevelopment (Cambridge, England) · 2024-11-21
Macrophages are required to coordinate mouse digit tip regeneration.
Read publicationScientific reports · 2024-11-21
Repurposing ketoconazole as an exosome directed adjunct to sunitinib in treating renal cell carcinoma.
Read publicationCancer letters · 2024-11-21
Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.
Read publicationExperimental biology and medicine (Maywood, N.J.) · 2017-03-20
MicroRNAs in prostate cancer: From function to biomarker discovery.
Read publicationExperimental biology and medicine (Maywood, N.J.) · 2024-11-21
Identification of microRNA signature and potential pathway targets in prostate cancer.
Read publicationCancers · 2024-11-21
Combination of Tipifarnib and Sunitinib Overcomes Renal Cell Carcinoma Resistance to Tyrosine Kinase Inhibitors via Tumor-Derived Exosome and T Cell Modulation.
Read publicationRegeneration (Oxford, England) · 2024-11-21
Epidermal closure regulates histolysis during mammalian (Mus) digit regeneration.
Read publicationRegeneration (Oxford, England) · 2024-11-21
The mammalian blastema: regeneration at our fingertips.
Read publicationDevelopment (Cambridge, England) · 2024-11-21
Macrophages are required to coordinate mouse digit tip regeneration.
Read publicationBrowse the latest scientific discoveries and advances from our lab.
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES · $243,175
Promoting Skeletal Regeneration in Aged Mice
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · $192,885
Spatiotemporal regulation of digit regeneration by sensory nerves
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · $64,226
The role of oxygen in blastema formation and skeletal regeneration
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